Research workbench
Crystal structure of human alpha N-terminal protein methyltransferase 1B
Analyse Crystal structure of human alpha N-terminal protein methyltransferase 1B in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5UBB
- Type
- protein
- Length
- 218 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha N-terminal protein methyltransferase 1B
- EC
- 2.1.1.299
- UniProt
- Q5VVY1
- Ligands
- SAM, UNX
- Pockets
- 2 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alpha N-terminal protein methyltransferase 1B (EC 2.1.1.299) | protein | 218 | 36% helix, 25% strand | Q5VVY1 |
Ligands and binding sites
- SAM · S-adenosylmethionine · ligand · chains A
- UNX · Unknown atom or ion · ion · 26 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 418 | 0.74 | 0.84 | 51 | SAM, UNX |
| 2 | 116 | 0.39 | 0.74 | 19 | UNX |
Compared structures
- 5UBB · Crystal structure of human alpha N-terminal protein methyltransferase 1B · the same entry in another collection · chain A against A, TM-score 1.00
- Q5VVY1 · AlphaFold monomer V2.0 prediction for alpha N-terminal protein methyltransferase 1B… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5VVY1
- Elsewhere: RCSB PDB 5UBB · PDBe 5UBB · UniProt Q5VVY1
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