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Second bromodomain of CDG4_1340 from cryptosporidium parvum, complexed with bromosporine

Analyse Second bromodomain of CDG4_1340 from cryptosporidium parvum, complexed with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5U9N
Type: protein
Length: 245 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bromo domain containing protein
UniProt: Q5CQB7
Ligands: BMF, SO4
Pockets: 1 · best druggability 0.78

Structure

x-ray diffraction · 2 distinct chains · 65% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Bromo domain containing protein	protein	125	64% helix, 0% strand	Q5CQB7
B	Bromo domain containing protein	protein	120	67% helix, 0% strand	Q5CQB7

Ligands and binding sites

BMF · Bromosporine · ligand · 2 copies · chains A, B
SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1032	0.78	0.80	76	BMF

Interfaces

1 interface between chains.

A–B · 298 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

5U9N · Second Bromodomain of cdg4_1340 from Cryptosporidium parvum, complexed with bromosporine · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5CQB7
Elsewhere: RCSB PDB 5U9N · PDBe 5U9N · UniProt Q5CQB7

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