Research workbench
Structure of the human HCN1 hyperpolarization-activated cyclic nucleotide-gated ion channel
Analyse Structure of the human HCN1 hyperpolarization-activated cyclic nucleotide-gated… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5U6O
- Type
- protein
- Length
- 1,928 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- POTASSIUM/SODIUM hyperpolarization-activated cyclic nucleotide-gated channel 1
- UniProt
- O60741
- Pockets
- 20 · best druggability 0.77
Structure
electron microscopy · 1 distinct chain · 65% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | POTASSIUM/SODIUM hyperpolarization-activated cyclic nucleotide-gated channel 1 | protein | 482 | 65% helix, 9% strand | O60741 |
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1001 | 0.77 | 0.79 | 150 | empty |
| 2 | 921 | 0.76 | 0.79 | 96 | empty |
| 3 | 758 | 0.75 | 0.80 | 88 | empty |
| 4 | 792 | 0.75 | 0.79 | 78 | empty |
| 5 | 1168 | 0.74 | 0.77 | 104 | empty |
Interfaces
6 interfaces between chains.
- A–D · 2964 Ų buried · 22 hydrogen bonds · protein-protein
- A–B · 2962 Ų buried · 22 hydrogen bonds · protein-protein
- B–C · 2959 Ų buried · 22 hydrogen bonds · protein-protein
- C–D · 2956 Ų buried · 22 hydrogen bonds · protein-protein
- A–C · 220 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 5U6O · Structure of the human HCN1 hyperpolarization-activated cyclic nucleotide-gated ion… · the same entry in another collection · chain A against A, TM-score 1.00
- O60741 · AlphaFold monomer V2.0 prediction for POTASSIUM/SODIUM hyperpolarization-activated cyclic… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60741
- Elsewhere: RCSB PDB 5U6O · PDBe 5U6O · UniProt O60741
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