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Crystal structure of the ATP-gated P2X7 ion channel in the closed, apo state

Analyse Crystal structure of the ATP-gated P2X7 ion channel in the closed, apo state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5U1L
Type: protein
Length: 317 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: P2X purinoceptor
UniProt: G1M6C4
Ligands: NAG
Pockets: 3 · best druggability 0.47

Structure

x-ray diffraction · 1 distinct chain · 20% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	P2X purinoceptor	protein	317	20% helix, 46% strand	G1M6C4

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	128	0.47	0.78	23	empty
2	118	0.40	0.75	24	empty
3	69	0.29	0.73	18	empty

Modifications

Observed in the structure: 5 disulfide, 2 glycan (disulfide, N-glycosylation).

Compared structures

5U1L · Crystal structure of the ATP-gated P2X7 ion channel in the closed, apo state · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G1M6C4
Elsewhere: RCSB PDB 5U1L · PDBe 5U1L · UniProt G1M6C4

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