UniProt G1M6C4
P2X purinoceptor (G1M6C4)
P2X purinoceptor (UniProt G1M6C4): 14 experimental structures on GenesisL1, 7 ligands bound, 12 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- G1M6C4
- Protein
- P2X purinoceptor
- Experimental structures
- 14
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 12 · 3 records with a druggable one
Structures
14 records of G1M6C4 in the MolNFT archive: 14 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5U1L | Crystal structure of the ATP-gated P2X7 ion channel in the closed, apo state | x-ray diffraction | A | NAG | 3 (best 0.47) |
| 5U1L | Crystal structure of the ATP-gated P2X7 ion channel in the closed, apo state | x-ray diffraction | A | NAG | — |
| 5U1U | Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist A740003 | x-ray diffraction | A | NAG, 7S4 | 2 (best 0.62) |
| 5U1U | Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist A740003 | x-ray diffraction | A | NAG, 7S4 | — |
| 5U1V | Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist A804598 | x-ray diffraction | A | NAG, 7S1 | 3 (best 0.54) |
| 5U1V | Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist A804598 | x-ray diffraction | A | NAG, 7S1 | — |
| 5U1W | Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist AZ10606120 | x-ray diffraction | A | NAG, 7RY | 2 (best 0.53) |
| 5U1W | Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist AZ10606120 | x-ray diffraction | A | NAG, 7RY | — |
| 5U1X | Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist JNJ47965567 | x-ray diffraction | A | NAG, 7RV | — |
| 5U1X | Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist JNJ47965567 | x-ray diffraction | A | NAG, 7RV | — |
| 5U1Y | Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist GW791343 | x-ray diffraction | A | NAG, 7RS | 2 (best 0.40) |
| 5U1Y | Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist GW791343 | x-ray diffraction | A | NAG, 7RS | — |
| 5U2H | Crystal structure of the ATP-gated P2X7 ion channel bound to ATP and allosteric antagonist A804598 | x-ray diffraction | A, B | NAG, 7S1, ATP | — |
| 5U2H | Crystal structure of the ATP-gated P2X7 ion channel bound to ATP and allosteric antagonist A804598 | x-ray diffraction | A, B | NAG, 7S1, ATP | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 14 records
- 7S1 · N-cyano-N'-[(1R)-1-phenylethyl]-N''-quinolin-5-ylguanidine · in 4 records
- 7RS · N~2~-(3,4-difluorophenyl)-N-{2-methyl-5-[(piperazin-1-yl)methyl]phenyl}glycinamide · in 2 records
- 7RV · N-{[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methyl}-2-(phenylsulfanyl)pyridine-3-carboxamide · in 2 records
- 7RY · N-[2-({2-[(2-hydroxyethyl)amino]ethyl}amino)quinolin-5-yl]-2-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]acetamide · in 2 records
- 7S4 · N-{(1R)-1-[N''-cyano-N'-(quinolin-5-yl) carbamimidamido]-2,2-dimethylpropyl}-2-(3,4-dimethoxyphenyl)acetamide · in 2 records
- ATP · Adenosine-5'-triphosphate · in 2 records
Elsewhere
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