Research workbench
Crystal structure of tim-barrel protein hisf-C9S
Analyse Crystal structure of tim-barrel protein hisf-C9S in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5TQL
- Type
- protein
- Length
- 498 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Imidazole glycerol phosphate synthase subunit hisf
- EC
- 4.1.3.-
- UniProt
- Q9X0C6
- Ligands
- PO4
- Pockets
- 2 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Imidazole glycerol phosphate synthase subunit hisf (EC 4.1.3.-) | protein | 249 | 39% helix, 26% strand | Q9X0C6 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 359 | 0.67 | 0.80 | 46 | PO4 |
| 2 | 418 | 0.65 | 0.79 | 46 | PO4 |
Interfaces
1 interface between chains.
- A–B · 567 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 5TQL · Crystal structure of TIM-Barrel protein HisF-C9S · the same entry in another collection · chain A against A, TM-score 1.00
- Q9X0C6 · AlphaFold monomer V2.0 prediction for imidazole glycerol phosphate synthase subunit hisf… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9X0C6
- Elsewhere: RCSB PDB 5TQL · PDBe 5TQL · UniProt Q9X0C6
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