Research workbench
Crystal structure of transport factor karyopherin-beta 2 in complex with the py-nls of ribosomal protein L4 (RPL4)
Analyse Crystal structure of transport factor karyopherin-beta 2 in complex with the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5TQC
- Type
- protein
- Length
- 847 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transportin-1,TRANSPORTIN-1; 60S ribosomal protein L4-like protein
- UniProt
- Q92973, G0SFC3
- Pockets
- 6 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 76% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transportin-1,TRANSPORTIN-1 | protein | 840 | 76% helix, 0% strand | Q92973 |
| B | 60S ribosomal protein L4-like protein | protein | 7 | 0% helix, 0% strand | G0SFC3 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 296 | 0.69 | 0.83 | 42 | empty |
| 2 | 88 | 0.47 | 0.81 | 11 | empty |
| 3 | 89 | 0.37 | 0.76 | 18 | empty |
| 4 | 63 | 0.30 | 0.75 | 13 | empty |
| 5 | 56 | 0.29 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 543 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 5TQC · Crystal structure of transport factor karyopherin-beta 2 in complex with the PY-NLS of… · the same entry in another collection · chain A against A, TM-score 1.00
- Q92973 · AlphaFold monomer V2.0 prediction for transportin-1 (Q92973) · a predicted model of the same protein · chain A against A, TM-score 0.84
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92973
- Every structure of UniProt G0SFC3
- Elsewhere: RCSB PDB 5TQC · PDBe 5TQC · UniProt Q92973 · UniProt G0SFC3
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