Research workbench
Crystal structure of rsv F in complex with human antibody HRSV90
Analyse Crystal structure of rsv F in complex with human antibody HRSV90 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5TPN
- Type
- protein
- Length
- 921 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusion glycoprotein F0,FIBRITIN; HRSV90 heavy chain; HRSV0 light chain
- UniProt
- P03420, Q38650
- Pockets
- 8 · best druggability 0.69
Structure
x-ray diffraction · 3 distinct chains · 18% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fusion glycoprotein F0,FIBRITIN | protein | 490 | 30% helix, 31% strand | P03420, Q38650 |
| H | HRSV90 heavy chain | protein | 217 | 3% helix, 50% strand | — |
| L | HRSV0 light chain | protein | 214 | 6% helix, 50% strand | — |
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 192 | 0.69 | 0.87 | 30 | empty |
| 2 | 423 | 0.57 | 0.74 | 51 | empty |
| 3 | 245 | 0.51 | 0.75 | 36 | empty |
| 4 | 144 | 0.50 | 0.79 | 20 | empty |
| 5 | 86 | 0.34 | 0.74 | 16 | empty |
Interfaces
3 interfaces between chains.
- H–L · 1706 Ų buried · 14 hydrogen bonds · protein-protein
- A–H · 586 Ų buried · 8 hydrogen bonds · protein-protein
- A–L · 460 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 11 disulfide (disulfide).
Compared structures
- 5TPN · Crystal structure of RSV F in complex with human antibody hRSV90 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03420
- Every structure of UniProt Q38650
- Elsewhere: RCSB PDB 5TPN · PDBe 5TPN · UniProt P03420 · UniProt Q38650
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