Research workbench
Crystal structure of the mitochondrial serine protease HTRA2
Analyse Crystal structure of the mitochondrial serine protease HTRA2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1LCY
- Type
- protein
- Length
- 296 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HTRA2 serine protease
- EC
- 3.4.21.-
- UniProt
- O43464
- Pockets
- 3 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 17% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HTRA2 serine protease (EC 3.4.21.-) | protein | 296 | 17% helix, 40% strand | O43464 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 276 | 0.65 | 0.81 | 43 | empty |
| 2 | 169 | 0.50 | 0.78 | 28 | empty |
| 3 | 92 | 0.39 | 0.76 | 17 | empty |
Compared structures
- 1LCY · Crystal Structure of the Mitochondrial Serine Protease HtrA2 · the same entry in another collection · chain A against A, TM-score 1.00
- O43464 · AlphaFold monomer V2.0 prediction for serine protease HTRA2, mitochondrial (O43464) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43464
- Elsewhere: RCSB PDB 1LCY · PDBe 1LCY · UniProt O43464
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