UniProt O43464
Serine protease HTRA2, mitochondrial (O43464)
Serine protease HTRA2, mitochondrial (UniProt O43464), EC 3.4.21.108: 21 experimental structures on GenesisL1, 3 ligands bound, 7 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O43464
- Protein
- Serine protease HTRA2, mitochondrial
- EC
- 3.4.21.108
- Experimental structures
- 21
- Predicted models
- 0
- Ligands
- 3
- Pockets
- 7 · 1 record with a druggable one
Structures
21 records of O43464 in the MolNFT archive: 21 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1LCY | Crystal Structure of the Mitochondrial Serine Protease HtrA2 | x-ray diffraction | A | — | — |
| 1LCY | Crystal structure of the mitochondrial serine protease HTRA2 | x-ray diffraction | A | — | — |
| 2PZD | Crystal Structure of the HtrA2/Omi PDZ Domain Bound to a Phage-Derived Ligand (WTMFWV) | x-ray diffraction | A, B | — | — |
| 2PZD | Crystal structure of the HTRA2/OMI PDZ domain bound to a phage-derived ligand (wtmfwv) | x-ray diffraction | A, B | — | — |
| 5FHT | HtrA2 protease mutant V226K | x-ray diffraction | A | CL, K, NA | — |
| 5FHT | HTRA2 protease mutant V226K | x-ray diffraction | A | — | — |
| 5M3N | HTRA2 wild-type structure | x-ray diffraction | A | — | — |
| 5M3N | HTRA2 wild-type structure | x-ray diffraction | A | — | — |
| 5M3O | HTRA2 A141S mutant structure | x-ray diffraction | A | — | 2 (best 0.46) |
| 5M3O | HTRA2 A141S mutant structure | x-ray diffraction | A | — | — |
| 5TNY | HTRA2 G399S mutant | x-ray diffraction | A | — | 3 (best 0.63) |
| 5TNY | HTRA2 G399S mutant | x-ray diffraction | A | — | — |
| 5TNZ | HtrA2 S142D mutant | x-ray diffraction | A | NA | 2 (best 0.46) |
| 5TNZ | HTRA2 S142D mutant | x-ray diffraction | A | NA | — |
| 5TO0 | HTRA2 S276C mutant | x-ray diffraction | A | — | — |
| 5TO1 | HTRA2 exposed (L266R, F303A) mutant | x-ray diffraction | A | CL | — |
| 5WYN | HtrA2 Pathogenic Mutant | x-ray diffraction | A | CL | — |
| 5WYN | HTRA2 pathogenic mutant | x-ray diffraction | A | CL | — |
| 7VGE | Structure of the PDZ deleted variant of HTRA2 protease (S306A) | x-ray diffraction | A, B, C, D, E, F | — | — |
| 8AUK | Cryo-EM structure of human BIRC6 in complex with HTRA2. | electron microscopy | D, E, C | — | — |
| O43464 | AlphaFold monomer V2.0 prediction for serine protease HTRA2, mitochondrial (O43464) | — | — | — |
Ligands
Elsewhere
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