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Hnrnp A18 RNA recognition motif

Analyse Hnrnp A18 RNA recognition motif in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5TBX
Type: protein
Length: 175 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cold-inducible RNA-binding protein
UniProt: Q14011
Ligands: NI
Pockets: 1 · best druggability 0.30

Structure

x-ray diffraction · 2 distinct chains · 25% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cold-inducible RNA-binding protein	protein	83	27% helix, 36% strand	Q14011
B	Cold-inducible RNA-binding protein	protein	92	24% helix, 39% strand	Q14011

Ligands and binding sites

NI · Nickel (II) ion · metal · chains A
ACT · Acetate ion · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	54	0.30	0.76	16	empty

Interfaces

1 interface between chains.

A–B · 14 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

5TBX · hnRNP A18 RNA Recognition Motif · the same entry in another collection · chain A against A, TM-score 1.00
Q14011 · AlphaFold monomer V2.0 prediction for cold-inducible RNA-binding protein (Q14011) · a predicted model of the same protein · chain A against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14011
Elsewhere: RCSB PDB 5TBX · PDBe 5TBX · UniProt Q14011

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