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Crystal structure of isoform 2 of purine nucleoside phosphorylase complexed with cytidine

Analyse Crystal structure of isoform 2 of purine nucleoside phosphorylase complexed… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5TBT
Type: protein
Length: 283 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Purine nucleoside phosphorylase
EC: 2.4.2.1
UniProt: A0A0U3AGT1
Ligands: CTN, SO4
Pockets: 1 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Purine nucleoside phosphorylase (EC 2.4.2.1)	protein	283	39% helix, 23% strand	A0A0U3AGT1

Ligands and binding sites

CTN · 4-amino-1-beta-D-ribofuranosyl-2(1H)-pyrimidinone · ligand · chains A
SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	313	0.64	0.80	42	CTN, SO4

Compared structures

5TBT · Crystal Structure of Isoform 2 of Purine Nucleoside Phosphorylase complexed with Cytidine · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0U3AGT1
Elsewhere: RCSB PDB 5TBT · PDBe 5TBT · UniProt A0A0U3AGT1

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