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Crystal structure of human importin A3 bound to RCC1
Analyse Crystal structure of human importin A3 bound to RCC1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5TBK
- Type
- protein
- Length
- 6,677 residues
- Chains
- 16
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-3; Regulator of chromosome condensation
- UniProt
- O00629, P18754
- Pockets
- 20 · best druggability 0.81
Structure
x-ray diffraction · 5 distinct chains · 46% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, G, H | Importin subunit alpha-3 | protein | 417 | 75% helix, 0% strand | O00629 |
| B, D | Importin subunit alpha-3 | protein | 415 | 73% helix, 0% strand | O00629 |
| E, F | Importin subunit alpha-3 | protein | 416 | 73% helix, 0% strand | O00629 |
| I, M, P | Regulator of chromosome condensation | protein | 419 | 4% helix, 38% strand | P18754 |
| K, L, N, O, J | Regulator of chromosome condensation | protein | 418 | 4% helix, 39% strand | P18754 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 817 | 0.81 | 0.84 | 88 | empty |
| 2 | 888 | 0.80 | 0.83 | 102 | empty |
| 3 | 994 | 0.80 | 0.81 | 114 | empty |
| 4 | 1106 | 0.78 | 0.80 | 97 | empty |
| 5 | 1030 | 0.77 | 0.79 | 97 | empty |
Interfaces
20 interfaces between chains.
- E–L · 2072 Ų buried · 25 hydrogen bonds · protein-protein
- A–K · 2067 Ų buried · 35 hydrogen bonds · protein-protein
- H–O · 2004 Ų buried · 20 hydrogen bonds · protein-protein
- C–J · 2000 Ų buried · 31 hydrogen bonds · protein-protein
- D–P · 1962 Ų buried · 37 hydrogen bonds · protein-protein
Compared structures
- 5TBK · Crystal structure of human importin a3 bound to RCC1 · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00629
- Every structure of UniProt P18754
- Elsewhere: RCSB PDB 5TBK · PDBe 5TBK · UniProt O00629 · UniProt P18754
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