Research workbench
Crystal structure of the fluoroacetate dehalogenase RPA1163 - ASP110ASN - apo no halide
Analyse Crystal structure of the fluoroacetate dehalogenase RPA1163 - ASP110ASN - apo… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5T4T
- Type
- protein
- Length
- 596 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fluoroacetate dehalogenase
- EC
- 3.8.1.3
- UniProt
- Q6NAM1
- Pockets
- 2 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Fluoroacetate dehalogenase (EC 3.8.1.3) | protein | 295 | 46% helix, 17% strand | Q6NAM1 |
| A | Fluoroacetate dehalogenase (EC 3.8.1.3) | protein | 301 | 46% helix, 16% strand | Q6NAM1 |
Ligands and binding sites
- ACT · Acetate ion · additive · 4 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 192 | 0.53 | 0.78 | 33 | empty |
| 2 | 118 | 0.42 | 0.76 | 25 | empty |
Interfaces
1 interface between chains.
- B–A · 1099 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 5T4T · Crystal Structure of the Fluoroacetate Dehalogenase RPA1163 - Asp110Asn - Apo No Halide · the same entry in another collection · chain B against B, TM-score 1.00
- Q6NAM1 · AlphaFold monomer V2.0 prediction for fluoroacetate dehalogenase (Q6NAM1) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6NAM1
- Elsewhere: RCSB PDB 5T4T · PDBe 5T4T · UniProt Q6NAM1
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