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Crystal structure of frizzled 7 crd

Analyse Crystal structure of frizzled 7 crd in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5T44
Type: protein
Length: 233 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Frizzled-7
UniProt: O75084
Pockets: 1 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 42% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Frizzled-7	protein	117	43% helix, 8% strand	O75084
B	Frizzled-7	protein	116	42% helix, 8% strand	O75084

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	136	0.65	0.87	22	empty

Interfaces

1 interface between chains.

A–B · 777 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 10 disulfide (disulfide).

Compared structures

5T44 · Crystal structure of Frizzled 7 CRD · the same entry in another collection · chain A against A, TM-score 1.00
O75084 · AlphaFold monomer V2.0 prediction for frizzled-7 (O75084) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75084
Elsewhere: RCSB PDB 5T44 · PDBe 5T44 · UniProt O75084

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