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Crystal structure of the non-desensitizing GLUR2 ligand binding core mutant (S1S2J-L483Y) in complex with antagonist dnqx at 2.3 a resolution
Analyse Crystal structure of the non-desensitizing GLUR2 ligand binding core mutant… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1LB9
- Type
- protein
- Length
- 514 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor 2
- UniProt
- P19491
- Ligands
- DNQ, SO4
- Pockets
- 4 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Glutamate receptor 2 | protein | 257 | 37% helix, 20% strand | P19491 |
Ligands and binding sites
- DNQ · 6,7-dinitroquinoxaline-2,3-dione · ligand · 2 copies · chains A, B
- SO4 · Sulfate ion · ion · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 520 | 0.77 | 0.84 | 75 | empty |
| 2 | 205 | 0.67 | 0.85 | 34 | SO4, DNQ |
| 3 | 206 | 0.65 | 0.84 | 30 | DNQ |
| 4 | 243 | 0.60 | 0.81 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 933 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1LB9 · Crystal structure of the Non-desensitizing GluR2 ligand binding core mutant (S1S2J-L483Y)… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19491
- Elsewhere: RCSB PDB 1LB9 · PDBe 1LB9 · UniProt P19491
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