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The structure of the PP2A B56 subunit double phosphorylated BUBR1 complex
Analyse The structure of the PP2A B56 subunit double phosphorylated BUBR1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5SWF
- Type
- protein
- Length
- 331 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein phosphatase 2A 56 kda regulatory subunit gamma isoform; Double…
- UniProt
- Q13362
- Pockets
- 2 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 70% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein phosphatase 2A 56 kda regulatory subunit gamma isoform | protein | 323 | 72% helix, 0% strand | Q13362 |
| B | Double phosphorylated BUBR1 | protein | 8 | 0% helix, 0% strand | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 67 | 0.53 | 0.86 | 14 | empty |
| 2 | 104 | 0.41 | 0.77 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 586 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 5SWF · The structure of the PP2A B56 subunit double phosphorylated BubR1 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q13362 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 2A 56 kda… · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13362
- Elsewhere: RCSB PDB 5SWF · PDBe 5SWF · UniProt Q13362
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