Research workbench
Pandda analysis group deposition FORM1 MAP kinase P38-alpha -- fragment N01381C in complex with MAP kinase P38-alpha
Analyse Pandda analysis group deposition FORM1 MAP kinase P38-alpha -- fragment N01381C… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5R8Z
- Type
- protein
- Length
- 348 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitogen-activated protein kinase 14
- EC
- 2.7.11.24
- UniProt
- P47811
- Ligands
- SN4, MG, CL, SO4
- Pockets
- 5 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitogen-activated protein kinase 14 (EC 2.7.11.24) | protein | 348 | 41% helix, 14% strand | P47811 |
Ligands and binding sites
- SN4 · 6-methoxypyridine-3-carbothioamide · ligand · chains A
- MG · Magnesium ion · metal · chains A
- CL · Chloride ion · ion · 6 copies · chains A
- SO4 · Sulfate ion · ion · 3 copies · chains A
- ACT · Acetate ion · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 364 | 0.72 | 0.84 | 46 | SN4, ACT |
| 2 | 297 | 0.60 | 0.78 | 31 | CL, SO4 |
| 3 | 78 | 0.37 | 0.77 | 19 | CL |
| 4 | 76 | 0.32 | 0.74 | 15 | empty |
| 5 | 66 | 0.30 | 0.74 | 16 | empty |
Compared structures
- 5R8Z · PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment N01381c in… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P47811
- Elsewhere: RCSB PDB 5R8Z · PDBe 5R8Z · UniProt P47811
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