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Crystal structure of ADP-dependent glucokinase from a pyrococcus horikoshii

Analyse Crystal structure of ADP-dependent glucokinase from a pyrococcus horikoshii in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1L2L
Type: protein
Length: 432 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ADP-dependent glucokinase
EC: 2.7.1.2
UniProt: O58328
Pockets: 4 · best druggability 0.60

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ADP-dependent glucokinase (EC 2.7.1.2)	protein	432	49% helix, 20% strand	O58328

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	387	0.60	0.76	50	empty
2	137	0.46	0.77	18	empty
3	84	0.32	0.73	16	empty
4	54	0.31	0.77	8	empty

Compared structures

1L2L · Crystal structure of ADP-dependent glucokinase from a Pyrococcus Horikoshii · the same entry in another collection · chain A against A, TM-score 1.00
O58328 · AlphaFold monomer V2.0 prediction for ADP-dependent GLUCOSE/GLUCOSAMINE kinase (O58328) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O58328
Elsewhere: RCSB PDB 1L2L · PDBe 1L2L · UniProt O58328

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