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Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-[4-bromo-6-(CARBAMOYLAMINO)PYRIDIN-2-yl]-3-[5-(2-methoxyethyl)-4- methylthiophen-2-YL]SULFONYLUREA

Analyse Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5Q09
Type: protein
Length: 2,541 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fructose-1,6-bisphosphatase 1
EC: 3.1.3.11
UniProt: Q2TU34
Ligands: 96A
Pockets: 20 · best druggability 0.86

Structure

x-ray diffraction · 3 distinct chains · 39% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, E	Fructose-1,6-bisphosphatase 1 (EC 3.1.3.11)	protein	319	39% helix, 24% strand	Q2TU34
B, C, F, G, H	Fructose-1,6-bisphosphatase 1 (EC 3.1.3.11)	protein	317	39% helix, 25% strand	Q2TU34
D	Fructose-1,6-bisphosphatase 1 (EC 3.1.3.11)	protein	318	39% helix, 25% strand	Q2TU34

Ligands and binding sites

96A · N-{[4-bromo-6-(carbamoylamino)pyridin-2-yl]carbamoyl}-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide · ligand · 8 copies · chains A, C, B, D, E, G, F, H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	480	0.86	0.93	52	empty
2	1148	0.84	0.84	115	empty
3	512	0.69	0.79	67	empty
4	387	0.69	0.81	74	empty
5	489	0.67	0.78	49	empty

Interfaces

14 interfaces between chains.

A–B · 2399 Å² buried · 29 hydrogen bonds · protein-protein
C–D · 2378 Å² buried · 29 hydrogen bonds · protein-protein
G–H · 2363 Å² buried · 31 hydrogen bonds · protein-protein
E–F · 2346 Å² buried · 31 hydrogen bonds · protein-protein
F–H · 1314 Å² buried · 28 hydrogen bonds · protein-protein

Compared structures

5Q09 · Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q2TU34
Elsewhere: RCSB PDB 5Q09 · PDBe 5Q09 · UniProt Q2TU34

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