UniProt Q2TU34
Fructose-1,6-bisphosphatase 1 (Q2TU34)
Fructose-1,6-bisphosphatase 1 (UniProt Q2TU34), EC 3.1.3.11: 43 experimental structures on GenesisL1, 30 ligands bound, 347 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q2TU34
- Protein
- Fructose-1,6-bisphosphatase 1
- EC
- 3.1.3.11
- Experimental structures
- 43
- Predicted models
- 0
- Ligands
- 30
- Pockets
- 347 · 18 records with a druggable one
Structures
43 records of Q2TU34 in the MolNFT archive: 43 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5PZQ | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D | 93V | — |
| 5PZR | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D | 93S | 18 (best 0.83) |
| 5PZR | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D | 93S | — |
| 5PZS | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D | 93Y | — |
| 5PZT | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | 947 | 20 (best 0.81) |
| 5PZT | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | 947 | — |
| 5PZU | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D | 94D | — |
| 5PZV | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D | 94G | 20 (best 0.83) |
| 5PZV | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D | 94G | — |
| 5PZW | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D | 94J, AMZ | 20 (best 0.83) |
| 5PZW | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D | 94J, AMZ | — |
| 5PZX | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | 94S | 20 (best 0.85) |
| 5PZX | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | 94S | — |
| 5PZY | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | 94V | — |
| 5PZZ | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | 94Y | 20 (best 0.84) |
| 5PZZ | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | 94Y | — |
| 5Q00 | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | 95D | — |
| 5Q01 | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | 95G | 20 (best 0.85) |
| 5Q01 | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | 95G | — |
| 5Q02 | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D | 95J | 17 (best 0.83) |
| 5Q02 | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D | 95J | — |
| 5Q03 | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | 95M | — |
| 5Q04 | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | 95P | 20 (best 0.85) |
| 5Q04 | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | 95P | — |
| 5Q05 | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | 95S | 20 (best 0.85) |
| 5Q05 | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | 95S | — |
| 5Q06 | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D | 95V | 16 (best 0.83) |
| 5Q06 | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D | 95V | — |
| 5Q07 | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | 95Y | — |
| 5Q08 | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | 967 | — |
| 5Q09 | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | 96A | 20 (best 0.86) |
| 5Q09 | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D, E, F, G, H | 96A | — |
| 5Q0A | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D | 96D | 20 (best 0.84) |
| 5Q0A | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D | 96D | — |
| 5Q0B | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D | 96J | 20 (best 0.85) |
| 5Q0B | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11)… | x-ray diffraction | A, B, C, D | 96J | — |
| 5ZWK | Crystal structure of Human liver fructose-1,6-bisphoaphatase complex with fructose-1,6-bisphophate… | x-ray diffraction | A, B, C, D | FBP, AMP, MG | 20 (best 0.82) |
| 5ZWK | Crystal structure of human liver fructose-1,6-bisphoaphatase complex with fructose-1,6-bisphophate… | x-ray diffraction | A, B, C, D | FBP, AMP, MG | — |
| 6LS5 | Structure of human liver FBPase complexed with covalent allosteric inhibitor | x-ray diffraction | A, B, C, D | EUF, AMP, MG | 20 (best 0.88) |
| 6LS5 | Structure of human liver fbpase complexed with covalent allosteric inhibitor | x-ray diffraction | A, B, C, D | EUF, AMP, MG | — |
| 7WJV | Crystal structure of human liver FBPase complexed with an covalent inhibitor | x-ray diffraction | A, B, C, D | AMP, LSA, MG, PMQ | 20 (best 0.87) |
| 7WJV | Crystal structure of human liver fbpase complexed with an covalent inhibitor | x-ray diffraction | A, B, C, D | AMP, LSA, MG, PMQ | — |
| 8XBK | Crystal Structure of Human Liver Fructose-1,6-bisphosphatase Complexed with a Covalent Inhibitor | x-ray diffraction | A, B, C, D | YR9, MG | 16 (best 0.87) |
Ligands
- MG · Magnesium ion · in 7 records
- AMP · Adenosine monophosphate · in 6 records
- 93S · N,N'-{oxybis[(propane-3,1-diyl)carbamoyl]}bis(3-chlorobenzene-1-sulfonamide) · in 2 records
- 947 · N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide · in 2 records
- 94G · N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide · in 2 records
- 94J · N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide) · in 2 records
- 94S · N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-methoxy-3-(2-methylpropyl)benzene-1-sulfonamide · in 2 records
- 94Y · N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide · in 2 records
- 95G · N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-[(3,4-dichloro-1-methyl-1H-pyrazol-5-yl)oxy]benzene-1-sulfonamide · in 2 records
- 95J · N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(1,2-oxazol-3-yl)thiophene-2-sulfonamide · in 2 records
- 95P · 4-bromo-N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-chlorothiophene-2-sulfonamide · in 2 records
- 95S · N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide · in 2 records
- 95V · N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1, 3-thiazol-4-yl)benzene-1-sulfonamide · in 2 records
- 96A · N-{[4-bromo-6-(carbamoylamino)pyridin-2-yl]carbamoyl}-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide · in 2 records
- 96D · N-[(5-cyanopyrazin-2-yl)carbamoyl]-3-(difluoromethoxy) benzene-1-sulfonamide · in 2 records
- 96J · N-[(4-bromo-3-methyl-1,2-thiazol-5-yl)carbamoyl]-3-methylbenzene-1-sulfonamide · in 2 records
- AMZ · Aminoimidazole 4-carboxamide ribonucleotide · in 2 records
- EUF · 2-(ethyldisulfanyl)-1,3-benzothiazole · in 2 records
- FBP · 1,6-di-O-phosphono-beta-D-fructofuranose · in 2 records
- LSA · 1,2-benzisothiazol-3(2H)-one 1,1-dioxide · in 2 records
- PMQ · benzylcarbamic acid · in 2 records
- 93V · 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid · in 1 record
- 93Y · N,N'-(hexane-1,6-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide) · in 1 record
- 94D · {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid · in 1 record
- 94V · N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-chlorobenzene-1-sulfonamide · in 1 record
- 95D · 2-[(3-{[(5-bromo-1,3-thiazol-2-yl)carbamoyl]sulfamoyl}-1-methyl-1H-indol-7-yl)oxy]acetamide · in 1 record
- 95M · N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(2-methylpropyl)thiophene-2-sulfonamide · in 1 record
- 95Y · N-{[4-bromo-6-(morpholin-4-yl)pyridin-2-yl]carbamoyl}-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide · in 1 record
- 967 · N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-1-benzothiophene-3-sulfonamide · in 1 record
- YR9 · N-[2-[4-[(3-bromophenyl)carbamoylsulfamoyl]phenyl]ethyl]ethanamide · in 1 record
Elsewhere
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