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The high resolution structure of annexin III shows differences with annexin V

Analyse The high resolution structure of annexin III shows differences with annexin V in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1AXN
Type: protein
Length: 323 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Annexin III
UniProt: P12429
Ligands: CA
Pockets: 4 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 71% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Annexin III	protein	323	71% helix, 0% strand	P12429

Ligands and binding sites

CA · Calcium ion · metal · 5 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	74	0.56	0.88	25	empty
2	249	0.51	0.75	27	empty
3	121	0.47	0.79	20	empty
4	53	0.29	0.75	11	empty

Compared structures

1AXN · The high resolution structure of annexin III shows differences with annexin V · the same entry in another collection · chain A against A, TM-score 1.00
P12429 · AlphaFold monomer V2.0 prediction for annexin A3 (P12429) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P12429
Elsewhere: RCSB PDB 1AXN · PDBe 1AXN · UniProt P12429

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