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Structure of ovine serum albumin in P1 space group

Analyse Structure of ovine serum albumin in P1 space group in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5ORF
Type: protein
Length: 2,332 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Serum albumin
UniProt: P14639
Ligands: PRO
Pockets: 20 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 71% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Serum albumin	protein	583	71% helix, 0% strand	P14639

Ligands and binding sites

PRO · Proline · ligand · 11 copies · chains A, C, B, D
PGE · Triethylene glycol · additive · 6 copies · chains A, B, C, D
PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains A, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1003	0.85	0.86	100	empty
2	968	0.84	0.85	73	empty
3	559	0.84	0.90	72	empty
4	685	0.84	0.88	72	empty
5	571	0.82	0.87	71	empty

Interfaces

4 interfaces between chains.

A–B · 1002 Å² buried · 13 hydrogen bonds · protein-protein
C–D · 999 Å² buried · 2 hydrogen bonds · protein-protein
A–D · 785 Å² buried · 7 hydrogen bonds · protein-protein
A–C · 354 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 66 disulfide (disulfide).

Compared structures

5ORF · Structure of ovine serum albumin in P1 space group · the same entry in another collection · chain D against D, TM-score 1.00
P14639 · AlphaFold monomer V2.0 prediction for albumin (P14639) · a predicted model of the same protein · chain D against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P14639
Elsewhere: RCSB PDB 5ORF · PDBe 5ORF · UniProt P14639

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