Research workbench
Penicillin-binding protein 2X (PBP2X) from streptococcus pneumoniae in complex with oxacillin
Analyse Penicillin-binding protein 2X (PBP2X) from streptococcus pneumoniae in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5OIZ
- Type
- protein
- Length
- 651 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Penicillin-binding protein 2X
- UniProt
- P59676
- Ligands
- 1S6
- Pockets
- 7 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 29% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Penicillin-binding protein 2X | protein | 651 | 29% helix, 22% strand | P59676 |
Ligands and binding sites
- 1S6 · (2R,4S)-5,5-dimethyl-2-[(1R)-1-{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}-2-oxoethyl]-1,3-thiazolidine-4-carb oxylic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 316 | 0.76 | 0.88 | 44 | empty |
| 2 | 430 | 0.66 | 0.79 | 46 | 1S6 |
| 3 | 137 | 0.48 | 0.79 | 35 | empty |
| 4 | 96 | 0.39 | 0.77 | 22 | empty |
| 5 | 84 | 0.39 | 0.77 | 21 | empty |
Modifications
Observed in the structure: 1 covalent (covalent ligand).
Compared structures
- 5OIZ · Penicillin-Binding Protein 2X (PBP2X) from Streptococcus pneumoniae in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- P59676 · AlphaFold monomer V2.0 prediction for penicillin-binding protein 2X (P59676) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P59676
- Elsewhere: RCSB PDB 5OIZ · PDBe 5OIZ · UniProt P59676
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