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Crystal structure of human histamine-releasing factor (HRF/TCTP)

Analyse Crystal structure of human histamine-releasing factor (HRF/TCTP) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5O9L
Type: protein
Length: 316 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Translationally-controlled tumor protein
UniProt: P13693
Pockets: 2 · best druggability 0.61

Structure

x-ray diffraction · 2 distinct chains · 35% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Translationally-controlled tumor protein	protein	159	34% helix, 33% strand	P13693
B	Translationally-controlled tumor protein	protein	157	36% helix, 33% strand	P13693

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	299	0.61	0.79	42	empty
2	231	0.50	0.75	28	empty

Interfaces

1 interface between chains.

A–B · 576 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

5O9L · Crystal structure of human Histamine-Releasing Factor (HRF/TCTP) · the same entry in another collection · chain A against A, TM-score 1.00
P13693 · AlphaFold monomer V2.0 prediction for translationally-controlled tumor protein (P13693) · a predicted model of the same protein · chain B against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P13693
Elsewhere: RCSB PDB 5O9L · PDBe 5O9L · UniProt P13693

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