Research workbench

Asymmetric acrabz-tolc

Analyse Asymmetric acrabz-tolc in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5O66
Type: protein
Length: 6,544 residues
Chains: 15
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Outer membrane protein tolc; Multidrug efflux pump subunit acra; Multidrug efflux pump…
UniProt: P02930, P0AE07, P31224, P0AAX1
Pockets: 20 · best druggability 0.87

Structure

electron microscopy · 6 distinct chains · 53% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Outer membrane protein tolc	protein	428	66% helix, 16% strand	P02930
D, E, F, G, H, I	Multidrug efflux pump subunit acra	protein	340	23% helix, 23% strand	P0AE07
J	Multidrug efflux pump subunit acrb	protein	1044	53% helix, 19% strand	P31224
K, L	Multidrug efflux pump subunit acrb	protein	1033	54% helix, 18% strand	P31224
M	Multidrug efflux pump accessory protein acrz	protein	36	94% helix, 0% strand	P0AAX1
N, O	Multidrug efflux pump accessory protein acrz	protein	37	95% helix, 0% strand	P0AAX1

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1003	0.87	0.89	121	empty
2	1076	0.86	0.87	157	empty
3	508	0.83	0.89	73	empty
4	1051	0.81	0.82	106	empty
5	290	0.81	0.92	46	empty

Interfaces

36 interfaces between chains.

J–K · 3526 Å² buried · 46 hydrogen bonds · protein-protein
J–L · 3435 Å² buried · 41 hydrogen bonds · protein-protein
K–L · 2964 Å² buried · 45 hydrogen bonds · protein-protein
A–B · 2377 Å² buried · 59 hydrogen bonds · protein-protein
B–C · 2352 Å² buried · 62 hydrogen bonds · protein-protein

Compared structures

5O66 · Asymmetric AcrABZ-TolC · the same entry in another collection · chain K against K, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02930
Every structure of UniProt P0AE07
Every structure of UniProt P31224
Every structure of UniProt P0AAX1
Elsewhere: RCSB PDB 5O66 · PDBe 5O66 · UniProt P02930 · UniProt P0AE07 · UniProt P31224 · UniProt P0AAX1

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