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ADP-dependent glucokinase from pyrococcus horikoshii

Analyse ADP-dependent glucokinase from pyrococcus horikoshii in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5O0J
Type: protein
Length: 453 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ADP-dependent glucokinase
EC: 2.7.1.147
UniProt: O58328
Ligands: 8BR, GLC
Pockets: 2 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 47% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ADP-dependent glucokinase (EC 2.7.1.147)	protein	453	47% helix, 20% strand	O58328

Ligands and binding sites

8BR · 8-bromo-adenosine-5'-monophosphate · ligand · 2 copies · chains A
GLC · alpha-D-glucopyranose · sugar · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	738	0.83	0.86	83	8BR, GLC
2	76	0.53	0.85	18	empty

Compared structures

5O0J · ADP-dependent glucokinase from Pyrococcus horikoshii · the same entry in another collection · chain A against A, TM-score 1.00
O58328 · AlphaFold monomer V2.0 prediction for ADP-dependent GLUCOSE/GLUCOSAMINE kinase (O58328) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O58328
Elsewhere: RCSB PDB 5O0J · PDBe 5O0J · UniProt O58328

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