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Lim domain kinase 2 (LIMK2) in complex with th-300

Analyse Lim domain kinase 2 (LIMK2) in complex with th-300 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5NXD
Type: protein
Length: 542 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P53671
Ligands: 9D8

Structure

x-ray diffraction · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	—	protein	271	—	P53671

Ligands and binding sites

9D8 · 4-[(3-chlorophenyl)sulfamoyl]-~{N}-(phenylmethyl)-~{N}-propyl-benzamide · ligand · 2 copies · chains A, B
EDO · 1,2-ethanediol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5NXD · LIM Domain Kinase 2 (LIMK2) In Complex With TH-300 · the same entry in another collection · chain A against A, TM-score 1.00
P53671 · AlphaFold monomer V2.0 prediction for lim domain kinase 2 (P53671) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P53671
Elsewhere: RCSB PDB 5NXD · PDBe 5NXD · UniProt P53671

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