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Insight into the molecular recognition mechanism of the coactivator NCOA1 by STAT6

Analyse Insight into the molecular recognition mechanism of the coactivator NCOA1 by… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
5NWX
Type
protein
Length
115 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Nuclear receptor coactivator 1; Signal transducer and activator of transcription 6
EC
2.3.1.48
UniProt
P70365, P42226

Structure

x-ray diffraction · 2 distinct chains · 32% helix, 35% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ANuclear receptor coactivator 1 (EC 2.3.1.48)protein10028% helix, 40% strandP70365
BSignal transducer and activator of transcription 6protein1560% helix, 0% strandP42226

Interfaces

1 interface between chains.

  • A–B · 506 Ų buried · 2 hydrogen bonds · protein-protein

Compared structures

  • 5NWX · Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6 · the same entry in another collection · chain A against A, TM-score 1.00
  • P70365 · AlphaFold monomer V2.0 prediction for nuclear receptor coactivator 1 (P70365) · a predicted model of the same protein · chain A against A, TM-score 0.96
  • P42226 · AlphaFold monomer V2.0 prediction for signal transducer and activator of transcription 6… · a predicted model of the same protein · chain B against A, TM-score 0.69

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