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Crystal structure of the human TGF-beta type II receptor extracellular domain in complex with TGF-BETA3

Analyse Crystal structure of the human TGF-beta type II receptor extracellular domain… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
1KTZ
Type
protein
Length
188 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Transforming growth factor beta 3; TGF-beta type II receptor
EC
2.7.1.37
UniProt
P10600, P37173

Structure

x-ray diffraction · 2 distinct chains · 4% helix, 48% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ATransforming growth factor beta 3protein826% helix, 52% strandP10600
BTGF-beta type II receptor (EC 2.7.1.37)protein1063% helix, 45% strandP37173

Interfaces

1 interface between chains.

  • A–B · 524 Ų buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 9 disulfide (disulfide).

Compared structures

  • 1KTZ · Crystal Structure of the Human TGF-beta Type II Receptor Extracellular Domain in Complex… · the same entry in another collection · chain A against A, TM-score 1.00
  • P37173 · AlphaFold monomer V2.0 prediction for TGF-beta receptor type-2 (P37173) · a predicted model of the same protein · chain B against A, TM-score 0.95
  • P10600 · AlphaFold monomer V2.0 prediction for transforming growth factor beta-3 proprotein… · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

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