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Crystal structure of CLASP2 TOG1 domain

Analyse Crystal structure of CLASP2 TOG1 domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5NR4
Type: protein
Length: 426 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Clip-associating protein 2
UniProt: O75122
Pockets: 3 · best druggability 0.51

Structure

x-ray diffraction · 2 distinct chains · 78% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Clip-associating protein 2	protein	220	77% helix, 0% strand	O75122
B	Clip-associating protein 2	protein	206	78% helix, 0% strand	O75122

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	249	0.51	0.75	36	empty
2	106	0.40	0.76	23	empty
3	68	0.29	0.74	15	empty

Interfaces

1 interface between chains.

A–B · 911 Å² buried · 24 hydrogen bonds · protein-protein

Compared structures

5NR4 · Crystal structure of Clasp2 TOG1 domain · the same entry in another collection · chain A against A, TM-score 1.00
O75122 · AlphaFold monomer V2.0 prediction for clip-associating protein 2 (O75122) · a predicted model of the same protein · chain B against A, TM-score 0.82

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75122
Elsewhere: RCSB PDB 5NR4 · PDBe 5NR4 · UniProt O75122

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