Research workbench
X-ray structure of the N239C mutant of glic
Analyse X-ray structure of the N239C mutant of glic in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5NKJ
- Type
- protein
- Length
- 1,555 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proton-gated ion channel
- UniProt
- Q7NDN8
- Pockets
- 20 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Proton-gated ion channel | protein | 311 | 32% helix, 32% strand | Q7NDN8 |
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 569 | 0.86 | 0.91 | 55 | empty |
| 2 | 755 | 0.82 | 0.85 | 66 | empty |
| 3 | 787 | 0.82 | 0.85 | 66 | empty |
| 4 | 902 | 0.82 | 0.83 | 67 | empty |
| 5 | 829 | 0.82 | 0.84 | 75 | empty |
Interfaces
5 interfaces between chains.
- B–C · 2444 Ų buried · 21 hydrogen bonds · protein-protein
- C–D · 2435 Ų buried · 23 hydrogen bonds · protein-protein
- A–B · 2363 Ų buried · 23 hydrogen bonds · protein-protein
- A–E · 2340 Ų buried · 15 hydrogen bonds · protein-protein
- D–E · 2270 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7NDN8
- Elsewhere: RCSB PDB 5NKJ · PDBe 5NKJ · UniProt Q7NDN8
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