Research workbench
X-ray structure of the H235Q mutant of glic
Analyse X-ray structure of the H235Q mutant of glic in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5NJY
- Type
- protein
- Length
- 1,555 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proton-gated ion channel
- UniProt
- Q7NDN8
- Pockets
- 20 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Proton-gated ion channel | protein | 311 | 36% helix, 31% strand | Q7NDN8 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 587 | 0.81 | 0.86 | 59 | empty |
| 2 | 163 | 0.79 | 0.95 | 24 | empty |
| 3 | 160 | 0.78 | 0.94 | 23 | empty |
| 4 | 166 | 0.78 | 0.94 | 24 | empty |
| 5 | 162 | 0.78 | 0.94 | 22 | empty |
Interfaces
5 interfaces between chains.
- B–C · 2339 Ų buried · 17 hydrogen bonds · protein-protein
- C–D · 2288 Ų buried · 21 hydrogen bonds · protein-protein
- A–B · 2276 Ų buried · 18 hydrogen bonds · protein-protein
- A–E · 2247 Ų buried · 18 hydrogen bonds · protein-protein
- D–E · 2243 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7NDN8
- Elsewhere: RCSB PDB 5NJY · PDBe 5NJY · UniProt Q7NDN8
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