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Crystal structure of human LTA4H mutant E271A in complex with LTA4 (crystal form I)

Analyse Crystal structure of human LTA4H mutant E271A in complex with LTA4 (crystal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5NI2
Type: protein
Length: 607 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Leukotriene a-4 hydrolase
EC: 3.3.2.6
UniProt: P09960
Ligands: DJ3, YB, ZN
Pockets: 3 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Leukotriene a-4 hydrolase (EC 3.3.2.6)	protein	607	44% helix, 23% strand	P09960

Ligands and binding sites

DJ3 · 5S-5,6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid · ligand · chains A
YB · Ytterbium (III) ion · metal · 2 copies · chains A
ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1080	0.85	0.86	100	DJ3
2	295	0.62	0.79	40	empty
3	172	0.43	0.74	28	empty

Compared structures

5NI2 · Crystal structure of human LTA4H mutant E271A in complex with LTA4 (crystal form I) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P09960
Elsewhere: RCSB PDB 5NI2 · PDBe 5NI2 · UniProt P09960

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