Enah EVH1 in complex with ac-[2-cl-F]-[prom-1]-[prom-1]-oh

Structure

x-ray diffraction · 3 distinct chains.

Ligands and binding sites

• 8SE · (3~{S},7~{R},10~{R},13~{S})-4-[[(3~{S},7~{R},10~{R}, 13~{S})-4-[(2~{S})-2-acetamido-3-(2-chlorophenyl) propanoyl]-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-en-13-yl]carbonyl]-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylic acid · ligand · 4 copies · chains A, B, D, C
• 8SB · (3~{S},7~{R},10~{R},13~{S})-4-[[(3~{R},7~{S},10~{S}, 13~{R})-4-[(2~{S})-2-acetamido-3-(2-chlorophenyl) propanoyl]-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-en-13-yl]carbonyl]-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylic acid · ligand · chains A, B, C
• SO4 · Sulfate ion · ion · 9 copies · chains A, B, C, D
• CL · Chloride ion · ion · chains C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5NAJ · ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-1]-[ProM-1]-OH · the same entry in another collection · chain D against D, TM-score 1.00
• Q8N8S7 · AlphaFold monomer V2.0 prediction for protein enabled homolog (Q8N8S7) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q8N8S7
• Elsewhere: RCSB PDB 5NAJ · PDBe 5NAJ · UniProt Q8N8S7