Research workbench
Complex between the leucine zipper (lz) and centrosomin-motif 2 (CM2) domains of drosophila melanogaster centrosomin (cnn) - L535E mutant form
Analyse Complex between the leucine zipper (lz) and centrosomin-motif 2 (CM2) domains… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5MW0
- Type
- protein
- Length
- 222 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Centrosomin
- UniProt
- P54623
- Ligands
- ZN
- Pockets
- 1 · best druggability 0.54
Structure
x-ray diffraction · 4 distinct chains · 90% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Centrosomin | protein | 62 | 90% helix, 0% strand | P54623 |
| C | Centrosomin | protein | 49 | 86% helix, 0% strand | P54623 |
| D | Centrosomin | protein | 51 | 88% helix, 0% strand | P54623 |
| B | Centrosomin | protein | 60 | 93% helix, 0% strand | P54623 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 140 | 0.54 | 0.81 | 19 | empty |
Interfaces
6 interfaces between chains.
- A–B · 962 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 940 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 394 Ų buried · 0 hydrogen bonds · protein-protein
- C–B · 392 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 379 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 5MW0 · Complex between the Leucine Zipper (LZ) and Centrosomin-motif 2 (CM2) domains of… · the same entry in another collection · chain B against B, TM-score 1.00
- P54623 · AlphaFold monomer V2.0 prediction for centrosomin (P54623) · a predicted model of the same protein · chain D against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54623
- Elsewhere: RCSB PDB 5MW0 · PDBe 5MW0 · UniProt P54623
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