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Galactoside acetyltransferase in complex with coenzyme a

Analyse Galactoside acetyltransferase in complex with coenzyme a in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1KQA
Type: protein
Length: 600 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Galactoside O-acetyltransferase
EC: 2.3.1.18
UniProt: P07464
Ligands: COA
Pockets: 3 · best druggability 0.84

Structure

x-ray diffraction · 1 distinct chain · 19% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Galactoside O-acetyltransferase (EC 2.3.1.18)	protein	200	19% helix, 27% strand	P07464

Ligands and binding sites

COA · Coenzyme A · ligand · 3 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	975	0.84	0.85	104	COA
2	790	0.76	0.81	74	COA
3	757	0.76	0.80	72	COA

Interfaces

3 interfaces between chains.

A–C · 1606 Å² buried · 8 hydrogen bonds · protein-protein
B–C · 1601 Å² buried · 7 hydrogen bonds · protein-protein
A–B · 1561 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

1KQA · Galactoside acetyltransferase in complex with coenzyme a · the same entry in another collection · chain A against A, TM-score 1.00
P07464 · AlphaFold monomer V2.0 prediction for galactoside O-acetyltransferase (P07464) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07464
Elsewhere: RCSB PDB 1KQA · PDBe 1KQA · UniProt P07464

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