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Monobody MB(LCK_1) bound to lck-SH2

Analyse Monobody MB(LCK_1) bound to lck-SH2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5MTN
Type: protein
Length: 182 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein kinase lck; Monobody MB(LCK_1)
EC: 2.7.10.2
UniProt: P06239
Ligands: SO4
Pockets: 1 · best druggability 0.32

Structure

x-ray diffraction · 2 distinct chains · 9% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein kinase lck (EC 2.7.10.2)	protein	88	19% helix, 33% strand	P06239
B	Monobody MB(LCK_1)	protein	94	0% helix, 49% strand	—

Ligands and binding sites

SO4 · Sulfate ion · ion · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	72	0.32	0.75	15	empty

Interfaces

1 interface between chains.

A–B · 833 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

5MTN · Monobody Mb(Lck_1) bound to Lck-Sh2 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06239
Elsewhere: RCSB PDB 5MTN · PDBe 5MTN · UniProt P06239

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