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High-salt structure of ravz LIR2-fused human LC3B

Analyse High-salt structure of ravz LIR2-fused human LC3B in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5MS6
Type: protein
Length: 252 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Microtubule-associated proteins 1A/1B light chain 3B
UniProt: Q9GZQ8
Pockets: 2 · best druggability 0.42

Structure

x-ray diffraction · 2 distinct chains · 29% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Microtubule-associated proteins 1A/1B light chain 3B	protein	128	29% helix, 21% strand	Q9GZQ8
B	Microtubule-associated proteins 1A/1B light chain 3B	protein	124	30% helix, 21% strand	Q9GZQ8

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	152	0.42	0.74	23	empty
2	73	0.31	0.74	14	empty

Interfaces

1 interface between chains.

A–B · 521 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

5MS6 · High-salt structure of RavZ LIR2-fused human LC3B · the same entry in another collection · chain A against A, TM-score 1.00
Q9GZQ8 · AlphaFold monomer V2.0 prediction for microtubule-associated proteins 1A/1B light chain… · a predicted model of the same protein · chain B against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9GZQ8
Elsewhere: RCSB PDB 5MS6 · PDBe 5MS6 · UniProt Q9GZQ8

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