Research workbench

Kallikrein-related peptidase 8 calcium complex

Analyse Kallikrein-related peptidase 8 calcium complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5MS3
Type: protein
Length: 228 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Kallikrein-8
EC: 3.4.21.118
UniProt: O60259
Ligands: CA
Pockets: 1 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain · 9% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Kallikrein-8 (EC 3.4.21.118)	protein	228	9% helix, 35% strand	O60259

Ligands and binding sites

CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	84	0.37	0.76	24	empty

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

5MS3 · Kallikrein-related peptidase 8 calcium complex · the same entry in another collection · chain A against A, TM-score 1.00
O60259 · AlphaFold monomer V2.0 prediction for kallikrein-8 (O60259) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O60259
Elsewhere: RCSB PDB 5MS3 · PDBe 5MS3 · UniProt O60259

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.