Research workbench
Kinetic and structural changes in hsmtphers, induced by pathogenic mutations in human FARS2
Analyse Kinetic and structural changes in hsmtphers, induced by pathogenic mutations in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5MGW
- Type
- protein
- Length
- 406 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phenylalanine--tRNA ligase, mitochondrial
- EC
- 6.1.1.20
- UniProt
- O95363
- Ligands
- PHE
- Pockets
- 3 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phenylalanine--tRNA ligase, mitochondrial (EC 6.1.1.20) | protein | 406 | 32% helix, 27% strand | O95363 |
Ligands and binding sites
- PHE · Phenylalanine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 525 | 0.69 | 0.79 | 54 | PHE |
| 2 | 75 | 0.45 | 0.81 | 20 | empty |
| 3 | 108 | 0.35 | 0.74 | 17 | empty |
Compared structures
- 5MGW · Kinetic and Structural Changes in HsmtPheRS, Induced by Pathogenic Mutations in Human… · the same entry in another collection · chain A against A, TM-score 1.00
- O95363 · AlphaFold monomer V2.0 prediction for phenylalanine--tRNA ligase, mitochondrial (O95363) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95363
- Elsewhere: RCSB PDB 5MGW · PDBe 5MGW · UniProt O95363
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