UniProt O95363
Phenylalanine--tRNA ligase, mitochondrial (O95363)
Phenylalanine--tRNA ligase, mitochondrial (UniProt O95363), EC 6.1.1.20: 16 experimental structures and 1 predicted model on GenesisL1, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O95363
- Protein
- Phenylalanine--tRNA ligase, mitochondrial
- EC
- 6.1.1.20
- Experimental structures
- 16
- Predicted models
- 1
- Pockets
- 9 · 2 records with a druggable one
Structures
17 records of O95363 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3CMQ | Crystal structure of human mitochondrial phenylalanine tRNA synthetase | x-ray diffraction | A | — | — |
| 3CMQ | Crystal structure of human mitochondrial phenylalanine tRNA synthetase | x-ray diffraction | A | — | — |
| 3HFV | Crystal structure of human mitochondrial phenylalanyl-tRNA synthetase complexed with m-tyrosine | x-ray diffraction | A | — | — |
| 3HFV | Crystal structure of human mitochondrial phenylalanyl-tRNA synthetase complexed with M-tyrosine | x-ray diffraction | A | — | — |
| 3TEG | Bacterial and Eukaryotic Phenylalanyl-tRNA Synthetases Catalyze Misaminoacylation of tRNAPhe with… | x-ray diffraction | A | — | — |
| 3TEG | Bacterial and eukaryotic phenylalanyl-tRNA synthetases catalyze misaminoacylation of trnaphe with… | x-ray diffraction | A | — | — |
| 3TUP | Crystal structure of human mitochondrial PheRS complexed with tRNAPhe in the active open state | x-ray diffraction | A | — | — |
| 3TUP | Crystal structure of human mitochondrial phers complexed with trnaphe in the active open state | x-ray diffraction | A | — | — |
| 5MGH | Crystal structure of pathogenic mutants of human mitochodnrial PheRS | x-ray diffraction | A | — | — |
| 5MGH | Crystal structure of pathogenic mutants of human mitochodnrial phers | x-ray diffraction | A | — | — |
| 5MGU | Kinetic and Structural Changes in HsmtPheRS, Induced by Pathogenic Mutations in Human FARS2 | x-ray diffraction | A | — | — |
| 5MGU | Kinetic and structural changes in hsmtphers, induced by pathogenic mutations in human FARS2 | x-ray diffraction | A | — | — |
| 5MGV | Kinetic and Structural Changes in HsmtPheRS, Induced by Pathogenic Mutations in Human FARS2 | x-ray diffraction | A | — | 4 (best 0.68) |
| 5MGV | Kinetic and structural changes in hsmtphers, induced by pathogenic mutations in human FARS2 | x-ray diffraction | A | — | — |
| 5MGW | Kinetic and Structural Changes in HsmtPheRS, Induced by Pathogenic Mutations in Human FARS2 | x-ray diffraction | A | — | — |
| 5MGW | Kinetic and structural changes in hsmtphers, induced by pathogenic mutations in human FARS2 | x-ray diffraction | A | — | — |
| O95363 | AlphaFold monomer V2.0 prediction for phenylalanine--tRNA ligase, mitochondrial (O95363) | predicted | A | — | 5 (best 0.69) |
Experiment against prediction
- 5MGW chain A against the predicted model O95363: TM-score 0.99, RMSD 0.41 Å
- 5MGW chain A against the predicted model O95363: TM-score 0.99, RMSD 0.41 Å
- 5MGH chain A against the predicted model O95363: TM-score 0.99, RMSD 0.54 Å
- 5MGH chain A against the predicted model O95363: TM-score 0.99, RMSD 0.54 Å
- 5MGU chain A against the predicted model O95363: TM-score 0.99, RMSD 0.80 Å
- 5MGU chain A against the predicted model O95363: TM-score 0.99, RMSD 0.80 Å
- 3HFV chain A against the predicted model O95363: TM-score 0.99, RMSD 0.95 Å
- 3HFV chain A against the predicted model O95363: TM-score 0.99, RMSD 0.95 Å
- 5MGV chain A against the predicted model O95363: TM-score 0.99, RMSD 1.08 Å
- 5MGV chain A against the predicted model O95363: TM-score 0.99, RMSD 1.08 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.