MolNFT v1 · #80369 · protein + RNA
Crystal structure of human mitochondrial phers complexed with trnaphe in the active open state
3TUP · Phenylalanyl-tRNA synthetase, mitochondrial: “Crystal structure of human mitochondrial phers complexed with trnaphe in the active open state”. X-ray diffraction, 8 pockets (best druggability 0.72). MolNFT v1 #80369 on GenesisL1: 3D…
- PDB
- 3TUP
- Type
- protein + RNA
- Length
- 478 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phenylalanyl-tRNA synthetase, mitochondrial; Thermus thermophilus trnaphe
- EC
- 6.1.1.20
- UniProt
- O95363
- Pockets
- 8 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phenylalanyl-tRNA synthetase, mitochondrial (EC 6.1.1.20) | protein | 404 | 29% helix, 24% strand | O95363 |
| T | Thermus thermophilus trnaphe | rna | 74 | — | — |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 921 | 0.72 | 0.77 | 51 | empty |
| 2 | 428 | 0.66 | 0.79 | 48 | empty |
| 3 | 435 | 0.60 | 0.77 | 29 | empty |
| 4 | 160 | 0.45 | 0.75 | 28 | empty |
| 5 | 134 | 0.44 | 0.76 | 19 | empty |
Interfaces
1 interface between chains.
- A–T · 1227 Ų buried · 28 hydrogen bonds · protein-nucleic
Compared structures
- 3TUP · Crystal structure of human mitochondrial PheRS complexed with tRNAPhe in the active open… · the same entry in another collection · chain A against A, TM-score 1.00
- O95363 · AlphaFold monomer V2.0 prediction for phenylalanine--tRNA ligase, mitochondrial (O95363) · a predicted model of the same protein · chain A against A, TM-score 0.76
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95363
- Elsewhere: RCSB PDB 3TUP · PDBe 3TUP · UniProt O95363
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.