Research workbench

Human platelet profilin complexed with the L-PRO10 peptide

Analyse Human platelet profilin complexed with the L-PRO10 peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1AWI
Type: protein
Length: 286 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Profilin; L-PRO10
UniProt: P07737
Pockets: 1 · best druggability 0.42

Structure

x-ray diffraction · 2 distinct chains · 26% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Profilin	protein	138	28% helix, 31% strand	P07737
P	L-PRO10	protein	10	0% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	145	0.42	0.74	21	empty

Interfaces

3 interfaces between chains.

A–P · 371 Å² buried · 6 hydrogen bonds · protein-protein
B–P · 330 Å² buried · 5 hydrogen bonds · protein-protein
A–B · 101 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

1AWI · Human platelet profilin complexed with the L-PRO10 peptide · the same entry in another collection · chain A against A, TM-score 1.00
P07737 · AlphaFold monomer V2.0 prediction for profilin-1 (P07737) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07737
Elsewhere: RCSB PDB 1AWI · PDBe 1AWI · UniProt P07737

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