UniProt P07737
Profilin-1 (P07737)
Profilin-1 (UniProt P07737), EC 4.6.1.1: 31 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P07737
- Protein
- Profilin-1
- EC
- 4.6.1.1
- Experimental structures
- 31
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 19 · 2 records with a druggable one
Structures
32 records of P07737 in the MolNFT archive: 31 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AWI | Human platelet profilin complexed with the L-PRO10 peptide | x-ray diffraction | A, B | — | — |
| 1AWI | Human platelet profilin complexed with the L-PRO10 peptide | x-ray diffraction | A, B | — | — |
| 1CF0 | Human platelet profilin complexed with an L-PRO10-iodotyrosine peptide | x-ray diffraction | A, B | — | — |
| 1CF0 | Human platelet profilin complexed with an L-PRO10- iodotyrosine peptide | x-ray diffraction | A, B | — | — |
| 1CJF | Profilin binds proline-rich ligands in two distinct amide backbone orientations | x-ray diffraction | A, B | — | — |
| 1CJF | Profilin binds proline-rich ligands in two distinct amide backbone orientations | x-ray diffraction | A, B | — | — |
| 1FIK | Human platelet profilin I crystallized in low salt | x-ray diffraction | A | — | — |
| 1FIK | Human platelet profilin I crystallized in low salt | x-ray diffraction | A | — | — |
| 1FIL | Human platelet profilin I crystallized in high salt actin-binding protein | x-ray diffraction | A | — | — |
| 1FIL | Human platelet profilin I crystallized in high salt actin- binding protein | x-ray diffraction | A | — | — |
| 1PFL | Refined solution structure of human profilin I | solution nmr | A | — | — |
| 1PFL | Refined solution structure of human profilin I | solution nmr | A | — | — |
| 2PAV | Ternary complex of Profilin-Actin with the Last Poly-Pro of Human VASP | x-ray diffraction | P | — | — |
| 2PAV | Ternary complex of profilin-actin with the last poly-pro of human vasp | x-ray diffraction | P | — | — |
| 2PBD | Ternary complex of profilin-actin with the poly-PRO-GAB domain of VASP* | x-ray diffraction | P | — | — |
| 2PBD | Ternary complex of profilin-actin with the poly-pro-gab domain of vasp* | x-ray diffraction | P | — | — |
| 3CHW | Complex of Dictyostelium discoideum Actin with Profilin and the Last Poly-Pro of Human VASP | x-ray diffraction | P | — | — |
| 3CHW | Complex of dictyostelium discoideum actin with profilin and the last poly-pro of human vasp | x-ray diffraction | P | — | — |
| 4X1L | Structural basis for mutation-induced destabilization of Profilin 1 in ALS | x-ray diffraction | A | — | — |
| 4X1L | Structural basis for mutation-induced destabilization of profilin 1 in als | x-ray diffraction | A | — | — |
| 4X1M | Structural basis for mutation-induced destabilization of Profilin 1 in ALS | x-ray diffraction | A | — | — |
| 4X1M | Structural basis for mutation-induced destabilization of profilin 1 in als | x-ray diffraction | A | — | — |
| 4X25 | Structural basis for mutation-induced destabilization of Profilin 1 in ALS | x-ray diffraction | A, B | — | — |
| 4X25 | Structural basis for mutation-induced destabilization of profilin 1 in als | x-ray diffraction | A, B | — | — |
| 6NAS | Ternary complex of ac-alpha-actin with profilin and accoa-NAA80 | x-ray diffraction | P | — | — |
| 6NBE | Ternary Complex of Ac-Alpha-Actin with Profilin and CoA-NAA80 | x-ray diffraction | P | — | — |
| 6NBE | Ternary complex of ac-alpha-actin with profilin and CoA-NAA80 | x-ray diffraction | P | — | — |
| 6NBW | Ternary complex of BETA/GAMMA-actin with profilin and ancoa-NAA80 | x-ray diffraction | P | — | — |
| 7P1H | Structure of the V. vulnificus exoy-G-actin-profilin complex | electron microscopy | P | — | — |
| 8BR0 | ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin (residue Q3455 to L3863)… | x-ray diffraction | B, D | LAB, MN, CH1 | 18 (best 0.82) |
| 8RTY | Structure of the F-actin barbed end bound by Cdc12 and profilin (ring complex) at a resolution of… | electron microscopy | P | — | 1 (best 0.82) |
| P07737 | AlphaFold monomer V2.0 prediction for profilin-1 (P07737) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4X1L chain A against the predicted model P07737: TM-score 0.99, RMSD 0.40 Å
- 4X1L chain A against the predicted model P07737: TM-score 0.99, RMSD 0.40 Å
- 4X1M chain A against the predicted model P07737: TM-score 0.99, RMSD 0.52 Å
- 4X1M chain A against the predicted model P07737: TM-score 0.99, RMSD 0.52 Å
- 6NBE chain P against the predicted model P07737: TM-score 0.98, RMSD 0.57 Å
- 6NBE chain P against the predicted model P07737: TM-score 0.98, RMSD 0.57 Å
- 4X25 chain A against the predicted model P07737: TM-score 0.98, RMSD 0.57 Å
- 4X25 chain A against the predicted model P07737: TM-score 0.98, RMSD 0.57 Å
- 6NAS chain P against the predicted model P07737: TM-score 0.98, RMSD 0.60 Å
- 6NBW chain P against the predicted model P07737: TM-score 0.98, RMSD 0.61 Å
Elsewhere
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