MolNFT v1 · #3030 · protein

Human platelet profilin complexed with an L-PRO10- iodotyrosine peptide

1CF0 · Protein (profilin): “Human platelet profilin complexed with an L-PRO10- iodotyrosine peptide”. X-ray diffraction, 1 pocket (best druggability 0.40). MolNFT v1 #3030 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1CF0
Type: protein
Length: 285 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (profilin); Protein (L-PRO10-iodotyrosine)
UniProt: P07737
Pockets: 1 · best druggability 0.40

Structure

x-ray diffraction · 2 distinct chains · 27% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Protein (profilin)	protein	138	28% helix, 32% strand	P07737
C	Protein (L-PRO10-iodotyrosine)	protein	9	0% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	125	0.40	0.74	21	empty

Interfaces

3 interfaces between chains.

A–C · 421 Å² buried · 7 hydrogen bonds · protein-protein
B–C · 348 Å² buried · 5 hydrogen bonds · protein-protein
A–B · 97 Å² buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 1 modified (nonstandard).

Compared structures

1CF0 · Human platelet profilin complexed with an L-PRO10-iodotyrosine peptide · the same entry in another collection · chain A against A, TM-score 1.00
P07737 · AlphaFold monomer V2.0 prediction for profilin-1 (P07737) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07737
Elsewhere: RCSB PDB 1CF0 · PDBe 1CF0 · UniProt P07737

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