MolNFT v1 · #109418 · protein

Structural basis for mutation-induced destabilization of profilin 1 in als

4X25 · Profilin-1: “Structural basis for mutation-induced destabilization of profilin 1 in als”. X-ray diffraction, 1 pocket (best druggability 0.43). MolNFT v1 #109418 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4X25
Type: protein
Length: 265 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Profilin-1
UniProt: P07737
Pockets: 1 · best druggability 0.43

Structure

x-ray diffraction · 2 distinct chains · 29% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Profilin-1	protein	134	28% helix, 34% strand	P07737
B	Profilin-1	protein	131	30% helix, 33% strand	P07737

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	148	0.43	0.76	26	empty

Interfaces

1 interface between chains.

A–B · 299 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

4X25 · Structural basis for mutation-induced destabilization of Profilin 1 in ALS · the same entry in another collection · chain A against A, TM-score 1.00
P07737 · AlphaFold monomer V2.0 prediction for profilin-1 (P07737) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07737
Elsewhere: RCSB PDB 4X25 · PDBe 4X25 · UniProt P07737

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