COPS5(2-257) in complex with a azaindole (compound 4)

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 23% strand (DSSP).

Ligands and binding sites

• 7K1 · 1-[(3~{R})-3-(1~{H}-benzimidazol-2-yl)morpholin-4-yl]-3-[2-(4-methyl-2-phenyl-phenyl)-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]propan-1-one · ligand · chains A
• ZN · Zinc ion · metal · chains A
• MPD · (4S)-2-methyl-2,4-pentanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 5M5Q · COPS5(2-257) in complex with a azaindole (compound 4) · the same entry in another collection · chain A against A, TM-score 1.00
• Q92905 · AlphaFold monomer V2.0 prediction for COP9 signalosome complex subunit 5 (Q92905) · a predicted model of the same protein · chain A against A, TM-score 0.84

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q92905
• Elsewhere: RCSB PDB 5M5Q · PDBe 5M5Q · UniProt Q92905