UniProt Q92905
COP9 signalosome complex subunit 5 (Q92905)
COP9 signalosome complex subunit 5 (UniProt Q92905), EC 3.4.-.-: 17 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q92905
- Protein
- COP9 signalosome complex subunit 5
- EC
- 3.4.-.-
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 3 · 1 record with a druggable one
Structures
18 records of Q92905 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4D10 | Crystal structure of the COP9 signalosome | x-ray diffraction | E, M | — | — |
| 4D10 | Crystal structure of the COP9 signalosome | x-ray diffraction | E, M | — | — |
| 4D18 | Crystal structure of the COP9 signalosome | x-ray diffraction | E, M | — | — |
| 4D18 | Crystal structure of the COP9 signalosome | x-ray diffraction | E, M | — | — |
| 4F7O | Crystal structure of CSN5 | x-ray diffraction | A, B | — | — |
| 4F7O | Crystal structure of CSN5 | x-ray diffraction | A, B | — | — |
| 4WSN | Crystal structure of the COP9 signalosome, a P1 crystal form | x-ray diffraction | E, M, U, c, k, s | — | — |
| 5JOG | CRYSTAL STRUCTURE OF CSN5(2-257) IN COMPLEX WITH CNS5i-3 | x-ray diffraction | A | ZN, 6LT | — |
| 5JOG | Crystal structure of CSN5(2-257) in complex with CNS5I-3 | x-ray diffraction | A | — | — |
| 5JOH | CRYSTAL STRUCTURE OF CSN5(2-257) IN COMPLEX WITH CNS5i-1b | x-ray diffraction | A | ZN, 6M3 | — |
| 5JOH | Crystal structure of CSN5(2-257) in complex with CNS5I-1B | x-ray diffraction | A | — | — |
| 5M5Q | COPS5(2-257) in complex with a azaindole (compound 4) | x-ray diffraction | A | ZN, 7K1 | — |
| 6R6H | Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome | electron microscopy | E | ZN | 3 (best 0.81) |
| 6R6H | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | E | ZN | — |
| 6R7F | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | E | — | — |
| 6R7H | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | E | — | — |
| 6R7I | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | E | ZN | — |
| Q92905 | AlphaFold monomer V2.0 prediction for COP9 signalosome complex subunit 5 (Q92905) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 6 records
- 6LT · 3-(difluoromethyl)-N-{6-[(5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl}-1-(propan-2-yl)-1H-pyrazole-5-carboxamide · in 1 record
- 6M3 · 2'-chloro-6-[(5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-carbonitrile · in 1 record
- 7K1 · 1-[(3~{R})-3-(1~{H}-benzimidazol-2-yl)morpholin-4-yl]-3-[2-(4-methyl-2-phenyl-phenyl)-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]propan-1-one · in 1 record
Experiment against prediction
- 4D10 chain E against the predicted model Q92905: TM-score 0.95, RMSD 1.50 Å
- 4D10 chain E against the predicted model Q92905: TM-score 0.95, RMSD 1.50 Å
- 4D10 chain M against the predicted model Q92905: TM-score 0.95, RMSD 1.51 Å
- 4D10 chain M against the predicted model Q92905: TM-score 0.95, RMSD 1.51 Å
- 4WSN chain E against the predicted model Q92905: TM-score 0.95, RMSD 1.62 Å
- 4WSN chain M against the predicted model Q92905: TM-score 0.95, RMSD 1.62 Å
- 4WSN chain c against the predicted model Q92905: TM-score 0.95, RMSD 1.64 Å
- 4WSN chain U against the predicted model Q92905: TM-score 0.95, RMSD 1.64 Å
- 4WSN chain k against the predicted model Q92905: TM-score 0.94, RMSD 1.65 Å
- 4WSN chain s against the predicted model Q92905: TM-score 0.94, RMSD 1.66 Å
Elsewhere
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