Research workbench
Crystal structure of the PRP43-ADP-BEF3 complex (in hexagonal space group)
Analyse Crystal structure of the PRP43-ADP-BEF3 complex (in hexagonal space group) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5LTK
- Type
- protein
- Length
- 700 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43
- UniProt
- G0RY84
- Ligands
- ADP, BEF, MG, SO4
- Pockets
- 8 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43 | protein | 700 | 43% helix, 19% strand | G0RY84 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · chains A
- BEF · Beryllium trifluoride ion · ligand · chains A
- MG · Magnesium ion · metal · chains A
- SO4 · Sulfate ion · ion · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 988 | 0.76 | 0.79 | 85 | SO4 |
| 2 | 357 | 0.67 | 0.81 | 34 | empty |
| 3 | 249 | 0.63 | 0.81 | 34 | ADP, BEF, MG |
| 4 | 56 | 0.46 | 0.85 | 15 | empty |
| 5 | 173 | 0.46 | 0.75 | 34 | empty |
Compared structures
- 5LTK · Crystal structure of the Prp43-ADP-BeF3 complex (in hexagonal space group) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0RY84
- Elsewhere: RCSB PDB 5LTK · PDBe 5LTK · UniProt G0RY84
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